Can AB− donate blood to AB−?

Yes, AB− can donate red cells to AB−. The hospital’s crossmatch test confirms every unit before it is given, but the ABO and Rh rules allow it. ## Why AB− works for AB− Your red cells carry the antigens that AB− patients safely accept. Compatibility is decided by what is on the donor red cell versus the antibodies in the recipient’s plasma. ## Who else AB− can help AB− red cells can go to: AB−, AB+. Plasma works the opposite way: AB plasma (not AB− red cells) is what every patient can receive (see red cells vs plasma). ## Before any transfusion Even a compatible-on-paper unit goes through the crossmatch, the final lab check that mixes your cells with the patient’s plasma. Rules plus crossmatch together are why transfusion is safe by design.